Ro4-1539

Description

Ro4–1539 (furethylnorlevorphanol) is an opioid drug of the morphine series with a strong analgesic effect, first synthesized in the 1950s by the pharmaceutical company Hoffmann–La Roche, but after clinical trials it was never sold commercially, as it did not have a number of advantages over the already available opioid drugs.

Pharmacology, Pharmacodynamic

Studies have shown that Ro4–1539 acts as a potent agonist of the µ–opioid receptors and is about 30-60 times stronger than the generic drug levorphanol. This drug can act as a strong analgesic, causing sedation and euphoria.

Side effects

In chemical studies and tests, it is necessary to approach the dosages of this substance as carefully as possible, since high dosages of this substance, since high dosages of this substance can cause respiratory depression, vomiting, itching, delirium.

Application in medicine

Ro4-1539 is a designer research drug and has never been used for medical purposes.

Legal status

US: Schedule II

Technical Information:

Product Name Ro4-1539

Synonyms furethylnorlevorphanol, Ro4-1539 HCl

IUPAC Name (1R,9R,10R)-17-[2-(furan-2-yl)ethyl]-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-4-ol

17-(2-(Furan-2-yl)ethyl)-3-hydroxymorphinan

CAS Number  27767-85-7

Molecular Formula  C22H27NO2

Formula Weight 337.463 g·mol−1

InChi Code InChI=1S/C22H27NO2/c24-17-7-6-16-14-21-19-5-1-2-9-22(19,20(16)15-17)10-12-23(21)11-8-18-4-3-13-25-18/h3-4,6-7,13,15,19,21,24H,1-2,5,8-12,14H2/t19-,21+,22+/m0/s1

InChi Key ANCZOEKEGCHEKY-KSEOMHKRSA-N

SMILES C1CCC23CCN(C(C2C1)CC4=C3C=C(C=C4)O)CCC5=CC=CO5

Solubility

DMF: 10 mg/mL

DMSO: 15 mg/mL

Ethanol: 30 mg/mL

PBS (pH 7.2): 10 mg/mL

Formulation A crystalline solid

Purity ≥98%

Disclaimer of liability

Ro4-1539 is intended only as a substance for scientific and research purposes in special laboratory conditions in compliance with all standards and safety measures.

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-Product purity 98-99%.
-You will receive a ZIP Pack, a sealed aluminum foil package containing the research product.