Description
2-Methyl-AP-237(2-Me-AP-237, 2-methyl Buccinazine) is an opioid drug, also known as a derivative of AP-237(Buccinazine). This substance acts as an active agonist of mu-opioid receptors and is about 4 times more effective than morphine. This substance has become known since 2019 as a recreational drug, for research and scientific purposes.
Chemistry
2-Methyl-AP-237 is classified as 1-(2-methyl-4-(3-
phenyl-2-propene-1-yl)-1-piperazinyl)-1-butanone (CAS
98608-61-8) and is the methyl analog of AP-237(Buccinazine) and has a related structure.
Pharmacology, Pharmacodynamic
According to in vivo studies in mice, this substance is an agonist of mu-opioid receptors and can cause an algetic effect depending on the dosage, and also, like most opioids, causes sedative and ephoritic effects.
Dosage
The exact dosage is not known, due to the lack of proper medical research. It has been established that 2-Methyl-AP-237 is a potent analgesic with high opioid activity, therefore it is necessary to be extremely careful with dosages.
Legal status
The United States: List I.
Technical Information:
Product Name 2-Methyl-AP-237
Synonyms 2-Me-AP-237, 2-methyl Buccinazine
IUPAC Name 1-(4-cinnamyl-2-methylpiperazin-1-yl)butan-1-one
1-[2-methyl-
CAS Number 98608-61-8, 98608-59-4
Molecular Formula C18H26N2O
Formula Weight 286.42 g/mol
InChi Code InChI=1S/C18H26N2O/c1-3-8-18(21)20-14-13-19(15-16(20)2)12-7-11-17-9-5-4-6-10-17/h4-7,9-11,16H,3,8,12-15H2,1-2H3/b11-7+
InChi Key CRSFXYZFNAFVFC-YRNVUSSQSA-N
SMILES CCCC(=O)N1CCN(CC1C)CC=CC2=CC=CC=C2
Solubility
DMF: 10 mg/ml
DMSO: 15 mg/ml
Ethanol: 30 mg/ml
PBS (pH 7.2): 10 mg/ml
Formulation A crystalline solid
Purity ≥98%
Disclaimer of liability
2-Methyl-AP-237 is intended only as a substance for scientific and research purposes in special laboratory conditions in compliance with all standards and safety measures.
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